Held every three years since 2004, the Crossroads Guitar Festival has quickly become the ultimate guitar-concert event, where the world's greatest players perform together to raise funds for the Crossroads Centre in Antigua. Clapton founded this treatment and education facility in 1998 to help people suffering from chemical dependency.

2013 year's shows featured performances by Clapton, the Allman Brothers Band, Blake Mills, Buddy Guy, Derek Trucks, Doyle Bramhall II, Gary Clark Jr., Jeff Beck, John Mayer, Keith Richards, Keith Urban, Los Lobos, Robert Cray, Sonny Landreth, Steve Cropper, Vince Gill, Warren Haynes and more.